On 1 Apr 1730 when Isaac was 21, he first married
Mehitable Tyler (21660) , daughter of
Moses Tyler (16 Feb 1668-11 Oct 1732) &
Ruth Perley (8051) (4 Jun 1675-10 May 1738), in Wenham, MA.
Born on 10 Aug 1712 in Boxford, MA. Mehitable died in Boxford, MA, on 30 Dec 1742; she was 30.