10 Feb 1661/2 James married Elizabeth Adams, daughter of William Adams (-1661), in Wenham, MA. Born ca 1643 in Ipswich, MA. Elizabeth died in Wenham, MA 14 Feb 1703/4.

Children of James and Elizabeth (Adams) Moulton, born at Wenham:
    i. Jonathan Moulton, b. ca. 1670, d. 3 Dec 1727 at Wenham, m. 1st at Salem, MA, 5 Jan 1699/1700 Sarah Herrick (b. 15 Oct 1662 at Salem, d. 2 Sep 1712 at Wenham), m. 2nd 1722 Mary Leverett (d. 22 Oct 1728);
    ii. James Moulton, b. 8 Mar 1665/6;
    iii. John Moulton, b. 4 Oct 1668, d. 21 Nov 1755 at Wenham, m. at Beverly, MA, 16 Aug 1693 Sarah Conant (b. 14 Feb 1668/9 at Beverly, d. 3 Jan 1744/5 at Wenham);
    iv. William Moulton, b. ca. 1672, d. 29 Aug 1748 at Wenham, m. 1st ca. 1792 Mary, m. 2nd at Wenham 4 Jul 1695 Jane Conant (b. 20 Apr 1675 at Beverly); and
    v. Elizabeth Moulton, b. ca. 1673, d. 23 Nov 1720 at Ipswich, MA, m. Jacob clinton (b. ca. 1681 at Ipswich, d. there 17 Oct 1720).

On 20 Jun 1678 Samuel first married Sarah Phele in Wenham, MA. Sarah died in Rehoboth, MA on 6 May 1698.

On 18 Jul 1700 Samuel second married Elizabeth Norris in Salem, MA. Elizabeth died in Rehoboth, MA on 12 Dec 1747.

On 2 Dec 1662 Mary married Dea. James Friend in Wenham, MA. Born ca 1633 in England. James died in Wenham, MA 10 Feb 1717/8.