On 30 Dec 1742 Isaac married Thankful King (31866) , daughter of Ichabod King (17139) (Oct 1680-1753) & Judith Bates (14680) (17 Apr 1678-bef 1745), in Rochester, MA. Born on 4 Nov 1718 in Middleborough, MA. Thankful died in Rochester, MA, on 6 Oct 1817; she was 98.

Children of Isaac and Thankful (King) Snow, born at Rochester:
    i. Freeman Snow, b. 7 Dec 1743;
    ii. Prince Snow, b. 1 Jun 1746;
    iii. Sarah Snow, b. 5 Jun 1749;
    iv. David Snow, b. 21 Oct 1752;
    v. Jonathan Snow, b. 7 Dec 1755; and
    vi. Elisha Snow, b. 11 Jun 1759.