On 3 Oct 1745 when Isaiah was 23, he married
Kezia Holmes (25871) , daughter of
Joseph Holmes (poss. 3 Jun 1665-26 Jun 1733) &
Mary Brewster (10167) (10 Feb 1678/9-17 Apr 1761), in Kingston, MA.
Born 23 Mar 1718/9 in Plymouth, MA. Kezia died in Kingston, MA on 22 Jun 1787.