On 14 Feb 1782 when Isaac was 22, he married Mary Watson (54750) , daughter of Isaac Watson (38498) (ca 1737-ca 1795) & Sarah Cushing (40632) (13 Oct 1737-), in Cape Elizabeth, Cumberland County, Maine. Born ca 1762 in Cape Elizabeth, Cumberland County, Maine. Mary died in Limington, York County, Maine on 20 Jul 1822.