Daniel married Elizabeth Ann Riggs (59032) , daughter of Joseph Riggs (48307) (20 Jul 1746-15 May 1822) & Rachel Chatfield (abt 1745-11 May 1778). Born on 23 Apr 1769 in Seymour, CT. Elizabeth Ann died in Seymour, CT, on 9 Feb 1801; she was 31.

Children of Daniel and Elizabeth Ann (Riggs) Holbrook:
    i. Betsey (or Grace) Holbrook, m. Moses Riggs (b. 1787 at Oxford, son of Moses & Susannah (Tucker) Riggs);
    ii. Willis Holbrook, b. 1790, d. 29 Dec 1840;
    iii. Ann Maria Holbrook, b. 1792, m. Philo Riggs (b. ca. 1790 in Oxford);
    iv. Daniel Holbrook, b. 1794, d. 1 Jul 1872, m. 1817 Harriet M. Riggs (b. 8 Sep 1795, d. 11 Dec 1893, sister of Moses who married Daniel’s older sister Betsey);
    v. Harry Holbrook, b. 1796, d. 29 Sep 1828, m. 17 Jan 1819 Nancy Davis (daughter of Reuben & Anne Davis); and
    vi. Polly Holbrook, b.1798, d. 28 Jan 1833, m. 10 Nov 1832 Alva Davis (b. 1794, d. 25 Dec 1860, brother of Nancy who married Polly’s older brother Harry).