On 22 Aug 1667 when Manassah was 21, he married Mercy Peirce (12077) , daughter of John Peirce (4101) (ca 1617-17 Sep 1661) & Mary (-12 Jul 1647), in Charlestown, MA.106 Manasses Marston & Mercy Peirce were married by Mr. Ri. Russell. Mercy died aft 1716.49

Children of Manasseh and Mercy (Peirce) Marston, born at Salem:
    i. Mercy Marston, b. 23 Jun 1669, d. 11 Sep 1669;
    ii. Benjamin Marston, b. 30 Jul 1670;
    iii. Samuel Marston, b. 20 Dec 1674, d. Feb 1674/5;
    iv. Samuel Marston, b. 17 Mar 1676, d. 21 Jul 1676;
    v. Mercy Marston, b. 7 Aug 1677, m. ca. 1702 Nathaniel Marston (d. 1729 at Boston);
    vi. Manasseh Marston, b. ca. 1680;
    v. Mehitable Marston, b. 14 May 1682, m. Samuel King;
    vii. Lydia Marston, b. 7 Jan 1683/4, m. at Salem 6 Dec 1705 Christopher Babbage (b. 11 Nov 1678 at Salem); and
    viii. Susanna Marston, b. 29 Apr 1687, m. at Salem 24 Mar 1708/9 John Rogers.