On 11 Jun 1701 John married Hannah Deane, daughter of Isaac Deane (ca 1657-11 Apr 1700) & Hannah Leonard (ca 1659-6 Jan 1749), in Salem, MA. Born on 24 Apr 1683 in Taunton, Bristol County, Massachusetts. Hannah died in Salem, MA, on 1 Jul 1745; she was 62.

On 13 Feb 1701 Elizabeth married John Chapman in Salem, MA. Born on 3 May 1671 in Rowley, MA.

On 14 Aug 1706 when Joseph was 26, he married Margaret Cox in Salem, MA.

Children of Joseph and Margaret (Cox) Cook, born at Salem, include
    i. Joseph Cook, b. 17 Apr 1707;
    ii. James Cook, b 22 Mar 1709/10;
    iii. William Cook, b. 14 Jan 1711/2; and
    iv. Margaret Cook, b. 20 Aug 1714.

Ca 1710 Hannah married Thomas Purchase, son of Thomas Purchase (ca 1654-1681) & Elizabeth Williams (23 Jun 1660-15 Jun 1730). Born on 29 Jan 1679 in Lynn, MA. Thomas died in West Springfield, Hampden County, Massachusetts, on 27 Dec 1759; he was 80.

On 21 May 1721 when Lydia was 34, she married John Jacobs, son of George Jacobs (ca 1649-before 5 Mar 1716/7) & Rebecca Andrews (18 Feb 1646-aft 1717), in Salem, MA. Born on 18 Sep 1679 in Salem, MA. John died in Salem, MA bef 25 Jun 1764.

John first married Abigail Waters, second Lydia Cook.

On 17 Oct 1717 when Isaac was 28, he married Martha Annable, daughter of Robert Annable (ca 1662-3 Feb 1716/7) & Susanna Sparks (ca 1669-), in Salem, MA. Born say 1690.

On 22 Oct 1718 Ebenezer married Margaret Webb, daughter of Daniel Webb (ca 1651-) & Mary Becket (ca 1656-), in Salem, MA. Born on 24 May 1696.

Children of Ebenezer and Margaret (Webb) Cook, born at Salem:
    i. Ebenezer Cook, b. 25 Aug 1719;
    ii. John Cook, b. 20 Apr 1721;
    iii. Daniel Cook, b. 12 Oct 1722;
    iv. Samuel Cook, b. 12 Jul 1724;
    v. Jonathan Cook, b. 23 May 1727;
    vi. Benjamin Cook, b. 12 Jul 1729; and
    vii. Jonathan Cook, b. 19 Sep 1731.