On 25 Aug 1695 Samuel married Mary Fessenden in Lynn, MA.
Childrenn of Samuel and Mary (Fessenden) Newell, the first six born at Roxxbury, the last four at Brookline:
i. Mary Newell, b. 30 Sep 1697, m. 29 Aug 1728 Andrew Allard;
ii. Martha Newell, b. 29 Apr 1699;
iii. Mercy Newell, b. 16 Sep 1700;
iv. Samuel Newell, b. 10 Dec 1702, d. 3 Nov 1786 at Dudley, MA, m. Abigail Harris;
v. Sarah Newell, b. 8 May 1705, m. Nathaniel Hawes;
vi. Eunice Newell, b. 18 Sep 1707, m. 28 Mar 1733 John Smith;
vii. Thomas Newell, b. 4 Jan 1709, m. 7 Mar 1739 Alice Howe;
viii. John Newell, b. 3 Jan 1711, m. 31 May 1744 Susannah Child;
ix. Elizabeth Newell, b. 8 Oct 1714, bp. 31 Oct 1714 at Roxbury, m. at Brookline 16 Aug 1735 Jonathan Fessenden; and
x. Moses Newell, b. 10 Nov 1716, bp. 2 Dec 1716 at Roxbury, m. Sarah Garrish.