On 10 Nov 1743 when Isaac was 28, he married Irene Phelps (38361) , daughter of Cornelius Phelps (19063) (5 Mar 1698-16 Aug 1760) & Margaret Dewey (45854) (5 May 1702-), in Hebron, CT.331 Born on 11 Nov 1724 in Hebron, CT.331 Irene died in Richmnd, MA, on 21 Aug 1809; she was 84.

Children of Isaac and Irene (Phelps) Tilden, born at Hebron:
    i. Irene Tilden, b. 22 Feb 1746/7;
    ii. Judeth Tilden, b. 20 Apr 1749;
    iii. Isaiah Tilden, b. 9 Jul 1751;
    iv. Naomi Tilden, b. 6 Sep 1753;
    v. Rhoda Tilden, b. 12 Dec 1756; and
    vi. Theda Tilden, b. 15 Aug 1758.331