On 4 Oct 1700 when James was 25, he married
Elizabeth Locke, daughter of
Dea. William Locke (13 Dec 1628-16 Jun 1720) &
Mary Clark (10 Dec 1640-18 Jul 1715), in Woburn, MA.
Born on 4 Jan 1681 in Woburn, MA.124 Elizabeth died in Middletown, CT, on 25 Sep 1753; she was 72.
Children of James and Elizabeth (Locke) Markham, born at Middletown:
i. James Thomas Markham, b. 22 Nov 1701, d. 12 Apr 1776 at Middletown, m. 25 Sep 1745 Sarah Rumney (d. Nov 1793);
ii. Elizabeth Markham, b. 18 Jan 1703, d. ca. 1745, m. at Middletown 2 Nov 1727 David Foster (b. 4 Oct 1706 at Middletown, d. ca. 1786, son of David & Ann (Boarne) Foster);
iii. William Markham, b. 28 Jan 1705, d. 1 Oct 1752 at East Haddam, m. 1st at Haddam 7 Dec 1737 Esther Arnold (b. 2 Feb 1706 at Haddam, d. there 15 Oct 1746, dau. of Jonathan & Elizabeth (Smith) Arnold), m. 2nd Deborah Kerr;
iv. John Markham, b. 28 Dec 1707, d. 30 Mar 1788 at East Hampton, CT, m. 3 Nov 1748 Dinah Sears (b. 15 Aug 1723 at Yarmouth, MA, d. 19 Nov 1786 at East Hampton, dau. of Ebenezer & Sarah Sears);
v. Mary Markham, b. 14 May 1710, m. at Middletown 20 Jan 1745/6 Eleazer Vesey;
vi. Abigail Markham, b. 22 Jul 1712, d. before 1802, m. at Middletown 2 May 1739 Samuel Miller;
vii. Martha Markham, b. 18 Jun 1714, d. ca. 1804, m. at Norwich, CT, 7 Nov 1737 Elijah Bliss;
viii. Hannah Markham, b. 6 Sep 1716, m. Hackaliah Foster (b. 6 Aug 1715 at Middletown, son of David & Ann (Boarne) Foster); and
ix. Nathaniel Markham, b. 27 Feb 1718, d. 8 Jun 1731 at Middletown.