On 14 May 1707 Samuel married Hester Bushnell, daughter of William Bushnell (15 Feb 1648-9 Dec 1711) & Rebecca Stratton (aft 1652-14 May 1703), in Saybrook, CT.163 Born on 2 Nov 1683 in Saybrook, CT.163 Hester died on 1 Dec 1762; she was 79.

Children of Samuel and Hester (Bushnell) Wilcox, born at Middletown:
    i. Samuel Wilcox, b. 3 Jan 1708/9, d. bef. 17 Apr 1725;
    ii. John Wilcox, b. 1 Aug 1712, d. bef. 1725;
    iii. Jeremiah Wilcox, b. 20 Sep 1715, m.at Middletown 10 Nov 1744 Mary Stow;
    iv. William Wilcox, b. 1 Mar 1717/8, d. bef. 1725;
    v. Elijah Wilcox, b. 14 Jan 1720/1, m. 1st at Middletown 28 May 1747 Abigail Churchill, 2nd at Middletown 22 Aug 1759 Mercy/Mary Bushnell of Saybrook; and
    vi. Esther/Hester Wilcox, b. 22 Nov 1723.197

On 13 Nov 1711 when Francis was 24, he married Abigail Graves, daughter of John Graves (ca 1653-2 Dec 1730) & Sarah White (ca 1661-), in Middletown, CT.197 Born on 29 Oct 1687 in Hatfield, Hampshire County, Massachusetts. Abigail died in Middletown, CT, on 20 Nov 1773; she was 86. Buried in Cromwell Cemetery.

Children of Francis and Abigail (Graves) Wilcox, born at Middletown:
    i. Abigail Wilcox, b. 18 Oct 1712;
    ii. Elisha Wilcox, b. 25 May 1715;
    iii. Francis Wilcox, b. 9 Oct 1717;
    iv. Margery Wilcox, b. 4 Aug 1720;
    v. Rebecca Wilcox, b. 18 Feb 1722/3; and
    vi. Nathan Wilcox, b. 29 Apr 1730.197