Samuel married Sarah Camp (32163) , daughter of Samuel Camp (14936) (20 May 1675-13 Mar 1743/4) & Mary Baldwin (16883) (ca 1681-29 Oct 1733). Born ca 1723 in Milford, CT. Sarah was baptized in First Church of Milford, on 26 May 1723.64

Children of Samuel and Sarah (Camp) Merwin: Samuel, Levi, Nathan, Andrew, Isaac, Philo, Mary, and Sarah.