On 26 Nov 1746 Thomas married Susanna Latham (25420) , daughter of Capt. Chilton Latham (9940) (ca 1670-6 Aug 1751) & Susanna Kingman (12 Apr 1679-23 Jun 1776), in East Bridgewater, MA. Born on 20 May 1717 in Bridgewater, MA.501 Susanna died in East Bridgewater, MA, on 4 Nov 1800; she was 83.

Thomas and Susanna were first cousins once removed. His maternal grandfather and her father were brothers.

Children of Thomas and Susanna (Latham) Wade, born at East Bridgewater, include:
    i. Susanna Wade, b. 30 Jun 1748;
    ii. Robert Wade, b. 9 Dec 1750; and
    iii. Molly Wade, b. 27 Aug 1754.