On 12 Dec 1733 when John was 31, he married Mary Hawke (35307) , daughter of Ens. James Hawke (16835) (29 Sep 1683-10 Jul 1716) & Mary Gill (20930) (6 Sep 1686-25 Aug 1715), in Braintree, MA. Born on 13 Oct 1711 in Hingham, MA.45

Children of John and Mary (Hawke) (Thaxter) Hancock:
    i. Mary Hancock, b. 8 Apr 1735, d. 21 Jun 1779 at Cambridge, MA, m. at Bridgewater, MA, 9 Oct 1760 Dr. Richard Perkins;
    ii. John Hancock, b. 12 Jan 1736/7, d. 8 Oct 1793 at Fairfield, CT, m. there 28 Aug 1775 Dorothy Quincy (b. 10 May 1747 at Boston, d. there 3 Feb 1830, dau. of Edmund & Elizabeth (Wendall) Quincy), first signer of the Declaration of Independence, and for several years the Gov. of Massachusetts; and
    iii. Ebenezer Hancock, b. 15 Nov 1741, m. Elizabeth Lowell.