On 17 May 1720 when Nathaniel was 22, he married Abigail Coffin, daughter of Jethro Coffin (16 Sep 1663-1726) & Mary Gardner (27 May 1670-27 Oct 1767), in Bristol, RI. Born 12 Feb 1700/1 in Nantucket, MA. Abigail died in Nantucket, MA on 7 Jul 1782.

Children of Nathaniel and Abigail (Coffin) Woodbury:
    i. Mary Woodbury, b. 1 Aug 1721;
    ii. Abigail Woodbury, b. 2 Jun 1723;
    iii. Priscilla Woodbury, b. 2 May 1724;
    iv. Elizabeth Woodbury, b. ca. 1726;
    v. Nathaniel Woodbury, b. ca. 1728; and
    vi. John Woodbury, b. ca. 1732.