On 26 Sep 1745 when Isaac was 18, he first married
Sarah Esterbrooks, daughter of
Thomas Esterbrooks (ca 1693-) &
Joanna Wood (16 Feb 1690/1-3 Jul 1746), in Swansea, Bristol County, Massachusetts.
Born 12 Jan 1726/7 in Swansea, Bristol County, Massachusetts. Sarah died on 18 Oct 1770.
Children of Isaac and Sarah (Esterbrooks) Cole, born at Warren:
i. Joanna Cole, b. 20 Dec 1746, d. 28 Apr 1769;
ii. Ichabod Cole, b. 17 Dec 1748, d. 25 Feb 1841, m. at Warren 19 Dec 1773 Ruby Cole (d. 12 Oct 1825);
iii. Isaac Cole, b. 1 Oct 1755, d. 21 Oct 1823, m. 1st at Warren 12 Nov 1780 Phebe Peirce (b. 18 Sep 1756 at Warren, d. 24 Jan 1793, dau. of Samuel & Betty (Simmons) Peirce), m. 2nd at Warren 24 Feb 1799 Abigail Peirce (b. 10 Jun 1776, d. 1 Jan 1842 at Warren, sister of Isaac’s first wife Phebe);
iv. Thomas Cole, b. 1 Jul 1758, d. at Savannah, GA, m. 2 Apr 1781 Anna Vose (d. 12 jan 1840); and
v. Reuben Butts Cole, b. 12 Dec 1762, d. 15 Nov 1794 at Havana, Cuba, m. Mary..