On 11 Dec 1753 when Caleb was 26, he married Sarah Adams (30663) , daughter of Ens. Thomas Adams (40873) (5 May 1709-12 Dec 1768) & Bathsheba Bradford (13361) (8 Nov 1703-23 Dec 1773), in Kingston, MA. Born on 3 Dec 1732 in Kingston, MA. Sarah died in Kingston, MA, on 17 Apr 1818; she was 85.

On 2 Oct 1754 when Benjamin was 25, he married Mary Gray (43273) , daughter of Samuel Gray (25427) (23 Dec 1701/2-ca 1738) & Patience Wadsworth (23485) (20 Aug 1706-23 Apr 1782). Born on 11 Nov 1731 in Kingston, MA. Mary died in Kingston, MA, on 15 Jul 1812; she was 80.

Children of Benjamin and Mary (Gray) Cooke, born at Kingston:
    i. Elizabeth Cooke, b.19 Aug 1755;
    ii. Sarah Cooke, b. 20 May 1757, d. 1800 unmarried;
    iii. Elkanah Cooke, b. 17 May 1759, m. Chriatiana;
    iv. Faith Cooke, b. before 24 Apr1761, d. 16 Sep 1768;
    v. Caleb Cooke, b. 26 May 1763, d. 5 Oct 1782 at Kingston;
    vi. Lettice Cooke, b. 12 Oct 1765, m. Samuel Everson;
    vii. Eunice Cooke, b. 22 Sep 1767, d. after 1812;
    viii. Priscilla Cooke, b. 25 Jan 1770, d. 2 Jan 1780 at Kingston;
    ix. Patience Cooke, b. 9 Jan 1773, d. after 1812; and
    x. Molly Cooke, b. 19 Nov 1774.

On 20 Mar 1765 when Ephraim was 27, he married Louisa Ring (48785) , daughter of George Ring (40054) (19 May 1726-13 Jan 1776) & Lucretia Chipman (31426) (3 Oct 1727-12 Feb 1795), in Yarmouth, Nova Scotia. Born on 30 May 1748 in Kingston, MA. Louisa died in Yarmouth, Nova Scotia, on 16 Jan 1826; she was 77.

Children of Ephraim and Louisa (Ring) Cooke, born at Yarmouth:
    i. Ephraim Cooke, b. 15 Jan 1765;
    ii. Manassah Cooke, b. 7 Oct 1766;
    iii. Louisa Cooke, b. 17 Aug 1768;
    iv. Rebecca Cooke, b. 13 May 1770;
    v. Caleb Cooke, b. 15 Mar 1772;
    vi. Francis Cooke, b. 13 Jan 1774;
    vii. George Cooke, b. 10 Feb 1776;
    viii. John Cooke, b. 25 Nov 1776;
    ix. Ruth Cooke, b. 5 Jan 1778;
    x. Lydia Cooke, b. 7 Aug 1780; and
    xi. Amos Cooke, b. 7 Sep 1781.

On 2 Oct 1766 when Hannah was 27, she married Cyrus Simmons (41179) , son of Joshua Simmons (21450) (ca Jun 1688-15 Jan 1744) & Sarah Delano (31585) (ca 1700-), in Duxbury, MA. Born ca 1731 in Duxbury, MA. Cyrus died in Duxbury, MA on 4 Nov 1823.

On 13 Dec 1764 Rebecca married Francis Adams (44267) , son of John Adams (40875) (14 Jun 1714-15 Apr 1806) & Thankful Washburn (24569) (24 Feb 1714/5-15 Jan 1805), in Kingston, MA. Born on 14 Dec 1741 in Kingston, MA. Francis died in Kingston, MA, on 4 Feb 1825; he was 83.

On 3 Nov 1766 when Lydia was 22, she married Ebenezer Adams (44268) , son of John Adams (40875) (14 Jun 1714-15 Apr 1806) & Thankful Washburn (24569) (24 Feb 1714/5-15 Jan 1805), in Kingston, MA. Born on 17 Nov 1744 in Kingston, MA. Ebenezer died in Kingston, MA, on 24 Sep 1820; he was 75.