On 27 Nov 1754 when Isaac was 24, he married Prudence Warner (29787) , daughter of Capt. John Warner (12762) (10 Mar 1701-9 Dec 1762) & Mercy Curtis, in New Milford, CT.294 Born on 3 Dec 1733 in New Milford, CT.294 Prudence died in Hinesburgh, Chittenden County, Vermont, on 4 Oct 1801; she was 67.

On 18 Jan 1753 when Eunice was 18, she married Jonathan Clark (48458) , son of George Clark (30995) (ca 1707-28 Feb 1754) & Abigail Law (12 Mar 1709-9 Feb 1774), in New Milford, CT. Born ca 1729 in Milford, CT. Jonathan was baptized in Milford, CT, on 9 Apr 1729. Jonathan died in New Milford, CT in 1765.