On 29 Sep 1782 when John Thatcher was 23, he married Louisa Pomeroy (52980) , daughter of Dea. Noah Pomeroy (41746) (8 Oct 1725-17 Sep 1798) & Luranna Northam (36294) (25 May 1723-24 Feb 1806). Born on 3 Sep 1761 in Colchester, CT.117 Louisa died in Colchester, CT in 1840. Buried in Colchester Burying Ground.

Children of John and Louisa (Pomeroy) Otis, born at Colchester:
    i. Sarah Otis, b. 9 May 1784, m. Simeon Marcy;
    ii. John Thatcher Otis, b. 4 Aug 1786, m. Lucy Tucker Dart;
    iii. Louisa Otis, b. 27 Jun 1788, m. Dennison Smith;
    iv. Eunice Otis, b. 30 Mar 1794, d. 30 Dec 1814;
    v. Dorothy Otis, b. 13 Aug 1798, m. Noah W. Bridges;
    vi. Charles Pomeroy Otis, b. 22 Apr 1799, d. 7 Jan 1857; and
    vii. Israel Tainter Otis, b. 3 Jul 1805, d. 30 May 1889 at Exeter, NH, m. Olive Morgan Osgood (b. 4 Mar 1810 at Lebanon, CT, d. 6 Oct 1906, dau. of Erastus & Martha (Morgan) Osgood).