On 24 Mar 1827 when Jacobus was 21, he first married Adriana Huijssen in Terneuzen, Zeeland.94 Born ca 1805 in Zaamslag, Zeeland. Adriana died in Terneuzen, Zeeland on 20 Oct 1835.94

Adriana, dau. of Jacobus Huijssen & Cornelia de Bruijne.

On 1 Oct 1837 when Jacobus was 32, he second married Pieternella Wieland (65462) , daughter of Pieter Wieland (12 Jan 1787-7 Mar 1873) & Maria Tollenaar (61344) (12 Apr 1792-16 Dec 1824), in Terneuzen, Zeeland.94 Born on 12 Sep 1811 in Hoek, Zeeland.94 Pieternella died in Terneuzen, Zeeland, on 15 Jun 1852; she was 40.94

Children of Jacobus Dregmans and Pieternella Wieland, born at Terneuzen:
    i. Adriaantje Dregmans, b. 15 Mar 1838, d. 31 May 1908 at Terneuzen, m. Johannes Adriaan Tazelaar;
    ii. Pieter Dregmans, b. 26 Apr 1839, d. 17 Feb 1917 at Axel, m. Kaatje Mulder; and
    iii. Reinier Dregmans, b. 23 Jun 1840, d. 21 Apr 1899 at Terneuzen.