On 27 Feb 1711/2 when Edward was 39, he second married Sarah Elkins
, daughter of Thomas Elkins (-bef 29 Nov 1705) & Sarah Gutch (ca 1654-), in Eastham, MA.136 Born on 5 Jun 1674 in Salem, MA. Sarah died in Eastham, MA, on 28 Feb 1753; she was 78.136
Sarah first married James Mayo (as his second wife), second Dea. Edward Knowles, and third Hezekiah Doane.
Children of James and Sarah Mayo, born at Eastham:
i. Sarah Mayo, b. 14 Jan 1702/3;
ii. Henry Mayo, b. 3 May 1705; and
iii. John Mayo, b. 14 Oct 1707.
Children of Edward and Sarah (Elkins) (Mayo) Knowles, born at Eastham:136
i. Edward Knowles, b. 3 Feb 1713/4, d. 5 Dec 1799 at Eastham, m. 1st 29 May 1734 Ann (Doane) Knowles (b. 1706, d. 1 Aug 1777 at Eastham, dau. of Nathaniel & Mary Doane, widow of Edward’s cousin James Knowles), m. 2nd 7 May 1778 at Wellfleet, Eunice (———) Harding (d. 27 Sep 1780, widow), m. 3rd Lydia (———) Berry of Harwich.; and
ii. Hannah Knowles, b. 23 Jun 1717, not mentioned in her father’s will.25