Ca 1738 Isaac first married Ann Fisher, daughter of John Fisher (-bef 29 Dec 1745) & Sarah [Fisher] (-19 Jan 1765). Born on 30 Oct 1718 in Boston, MA. Ann died in Pembroke, MA bef Nov 1763.

For more on Ann’s parents, see see the article “Mary Fisher, wife of Jabez^5 Hatch (1709-1763)” by Frederick S. Sherman, NEGHS 155 (2001): 105-110.

Children of Isaac and Ann (Fisher) Hatch, born at Pembroke:
    i. Ann Hatch, b. 29 Jun 1739;
    ii. Lydia Hatch, b. 11 Jan 1740[/1];
    iii. Isaac Hatch, b. 4 Oct 1742;
    iv. Judith Hatch, b. 16 Feb 1744;
    v Sarah Hatch, b. 9 Jun 1747;
    vi. Clift Hatch, b. 23 Jun 1749;
    vii. Fisher Hatch, b. 28 Jun 1751;
    viii. Walter Hatch, twin, b. 28 Jun 1751;
    ix. William Hatch, b. 3 Dec 1754;
    x. John Hatch, b. 17 Jun 1756;
    xi. Jabez Hatch, b. 20 Dec 1759; and
    xii. Harris Hatch, b. 13 Sep 1760.395

On 28 Nov 1763 Isaac second married Sarah Humphrey (40479) , daughter of Thomas Humphrey (34658) (2 Feb 1687/8-10 Sep 1770) & Anna Lincoln (20904) (15 Sep 1690-5 May 1725), in Pembroke, MA.395 Born on 25 Sep 1722 in Hingham, MA. Sarah died in Pembroke, MA, on 30 May 1804; she was 81.395 Buried in Pembroke Centre Cemetery.

Sarah first married Nehemiah Cushing, second Isaac Hatch as his second wife.

Sarah died in her 82d year.395

Josiah married Marcy. Born ca 1708. Marcy died in Pembroke, MA on 19 Sep 1779.395 Buried in Pembroke Centre Cemetery.