On 2 Jul 1730 when Thankful was 19, she first married Thomas Hawes (31375) , son of Joseph Hawes (14115) (16 Jul 1673-5 Nov 1752) & Mary Howes (ca 1671-10 Jan 1728/9), in Barnstable, MA. Born ca 1701 in Yarmouth, MA. Thomas died in Yarmouth, MA in 1747.

In 1749 Thankful second married Stephen Skiffe (23843) , son of Stephen Skiffe (14 Apr 1641-8 Jun 1710) & Lydia Snow (9083) (ca 1642-13 Mar 1711), in Yarmouth, MA. Born on 4 Feb 1685 in Sandwich, MA.588 Stephen died in Sandwich, MA, on 4 Oct 1756; he was 71.

On 25 Mar 1758 when Thankful was 46, she third married Dea. Gershom Davis in Barnstable, MA. Born on 5 Sep 1702 in Barnstable, MA. Gershom died in Barnstable, MA, on 29 Apr 1790; he was 87.

24 Jan 1737/8 Isaac first married Hannah Hallett, daughter of John Hallett & Thankful Thatcher, in Barnstable, MA. Born on 17 Dec 1717. Hannah died in Barnstable, MA, on 19 Apr 1741; she was 23.

On 21 Sep 1742 when Isaac was 27, he second married Mary Cobb, daughter of Gershom Cobb & Hannah Davis, in Barnstable, MA. Born on 14 Jun 1721 in Barnstable, MA.