On 26 Oct 1715 when Isaac was 27, he married
Sarah Barlow, daughter of
John Barlow (ca 1669-Mar 1729/30) &
Elizabeth Dillingham (ca 1670-10 May 1759), in Plympton, MA.
Born on 15 Oct 1693 in Sandwich, MA. Sarah died in Plympton, MA, on 2 Jul 1733; she was 39.