On 27 Jan 1679 when James was 24, he married Eleanor Johnson, daughter of Thomas Johnson (-13 Aug 1683) & Priscilla Goznee (-30 Apr 1710), in Falmouth, MA. Born on 22 May 1661 in Sandwich, MA.

Children of James and Eleanor (Johnson) Lewis:
    i. John Lewis, b. 5 Feb 1680;
    ii. Eleanor Lewis, b. 3 Aug168;
    iii. Remember Lewis, b. 26 Dec 1684;
    iv. Deborah Lewis, b. 20 Aug 1686;
    v. Ebenezer Lewis, b. 22 Aug 1690;
    vi. Thomas Lewis, b. 22 Feb 1691;
    vii. Hannah Lewis, b. 14 Oct 1694;
    viii. Jacob Lewis, b. 6 Sep 1696;
    ix. Benjamin Lewis, b. 13 Jun 1698;
    x. James Lewis, b. 20 Jul 1700;
    xi. Bathsheba Lewis, b. 8 Apr 1701; and
    xii. Jemima Lewis, b. 3 Apr 1703.

Thomas married Jane.

Children of Thomas and Jane Lewis:
    i. John Lewis, b. ca. 1688, d. 5 Apr 1754, m. Elizabeth Mayo (d. 21 Oct 1757);
    ii. George Lewis, b. 6 May 1691, d. 1738, m. at Eastham 21 Jul 1716 Grace Snow (b. 5 Feb 1675, d. after 6 Jul 1714);
    iii. Nathaniel Lewis, b. 31 Mar 1696, m. Ann Gaines;
    iv. Rebecca Lewis, b. 17 Mar 1697, m. int. at Eastham 30 Sep 1718 William Dennis;
    v. Benjamin Lewis, b. 8 Oct 1700, m. at Truro 13 Jun 1728 Elizabeth Rogers (b. 27 Mar 1706);
    vi. Sarah Lewis, b. 2 Jun 1702, d. 1733, m. at Eastham 19 Oct 1721 Elisha Higgins (b. 3 Jan 1702, d. 22 Jar 1777;
    vii. Apphia Lewis, b. 9 May 1704, m. at Eastham 21 Feb 1728 William Twining (b. 2 Sep 1704, d. 17 Nov 1769);
    viii. Joseph Lewis, b. 19 Nov 1706 at Truro437;
    ix. Susanna Lewis, b. 19 Dec 1709/10 [sic] at Truro437;
    x. Thomas Lewis, b. 28 Mar 1711, d. before 1738, m. 1st at Truro 28 Mar 1711 Deborah Griffin, m. 2nd int. at Eastham 9 Feb 1722 Judith Smith.

22 Jan 1682/3 Mary married George Morey, son of George Morey, in Bristol, RI. Born ca 1658. George died in Bristol, RI in Dec 1713.

Benjamin married Elizabeth Crowe.