On 2 Jan 1728 when John was 24, he married Rebecca Fenno (44361) , daughter of John Fenno (29 Aug 1665-23 Apr 1741) & Rachel Newcomb (24809) (ca 1670-16 Oct 1750), in Boston, MA. Born on 8 Sep 1697 in Milton, MA. Rebecca died in Canton, Norfolk County, Massachusetts, on 13 Mar 1783; she was 85.

Children of John and Rebecca (Fenno) Peirce:
    i. Eliphalet Peirce, b. 29 Jul 1728 at Watertown, d. 3 Aug 1797 at Augusta, ME, m. at Stoughton, MA, 3 Apr 1755 Elizabeth Wheeler;
    ii. Seth Peirce, b. 5 Nov 1730;
    iii. Elizabeth Peirce, b. ca. 1734;
    iv. Abigail Peirce, b. ca. 1737;
    v. John Peirce, b. ca. 1740; and
    vi. Jesse Peirce.

4 Jan 1727/8 Jonas married Abigail Comee (39395) , daughter of John Comee (18 Oct 1665-6 Dec 1729) & Martha Munroe (20035) (2 Nov 1667-27 Mar 1730), in Lexington, MA.282 Born bef Oct 1707 in Lexington, MA. Abigail was baptized in Lexington, MA, on 26 Oct 1707.569

Abigail, of Lexington. Jonas and Abigail settled in Lexington. Their children:
    i. Jonas Peirce, b. 7 Jul 1730, m. 1st Sarah (d. 17 Sep 1772), m. 2nd 11 Feb 1773 Lydia Gregory;
    ii. Nathan Peirce, b. 15 Dec 1732, m. 26 Dec 1753 Sarah Reed of Lexington;
    iii. Elizabeth Peirce, b. 31 May 1735, m. 15 Nov 1753 TImothy Fessenden;
    iv. John Peirce, b. 14 Jul 1736;
    v. Thaddeus Peirce, b. 14 May 1739, d. 14 Dec 1760;
    vi. Solomon Peirce, b. 15 Jun 1742, d. 16 Oct 1821 at Arlington, MA, m. 15 Dec 1763 Amity Fessenden (b. 15 Jun 1743, dau. of Samuel & Elizabeth (Allen) Fessenden of Lexington);
    vii. Abigail Peirce, b. 3 Aug 1744, d. 1 Jan 1818, m. 30 Mar 1762 Nathan Derby of Westminster (b. 2 Aug 1737 at Accton, son of Andrew & Elizabeth (Patch) Derby); and
    viii. Mary Peirce, b. 7 Feb 1747.

On 17 Nov 1731 Ezekiel married Mercy Wellington, daughter of Ebenezer Wellington (ca 1682-) & Deliverance Bond (2 May 1686-), in Watertown, MA.30 Born on 26 May 1711.

Children of Ezekiel and Mercy (Wellington) Peirce:
    i. Jacob Peirce, b. 1732;
    ii. Ezekiel Peirce, b. 1734/5;
    iii. Sarah Peirce, bp. 13 Apr 1740; and
    iv. Ebenezer Peirce, bp. 17 Sep 1742.30

On 3 Jun 1739 when Samuel was 26, he married Abigail Stearns (39524) , daughter of George Stearns (20125) (1688-26 Jun 1760) & Hannah Sanderson (31 May 1689-21 May 1770), in Watertown, MA.30 Born ca 1713 in Waltham, MA. Abigail was baptized on 1 Jan 1715.30 Abigail died on 25 Jul 1796.30

Children of Samuel and Abigail (Stearns) Peirce, born at Waltham:
    i. Abigail, b. 25 May 1740, d. Sep 1747;
    ii. Samuel, b. 1 Nov 1741;
    iii. Elizabeth, b. 30 Sep 1743, m. 17 Dec 1761 Timothy Flagg;
    iv. Daniel, b. & d. 1746;
    v. Nathaniel, b. 1748, d. 1750;
    vi. Abigail, b. 12 Apr 1750, m. 4 Apr 1771 Jeremiah Knowlton of Lexington;
    vii. Judith, b. 8 Mar 1753, m. 26 Nov 1778 Elisha Stearns;
    viii. Ezra, b. 24 Dec 1755, d. 6 Aug 1795; and
    ix. Beulah, b. 8 Jul 1764, m. 30 Sep 1784 John Colburn; resided at Lincoln, MA.30

Daniel married Martha.

Children of Daniel and Martha Peirce:
    i. Henry Peirce, b. 1 Mar 1753;
    ii. Martha Peirce, bp. 22 Dec 1754, and
    iii. Anna Peirce, bp. 27 Jul 1768.30

On 25 Dec 1745 when Jonathan was 21, he married Abigail Blanchard, daughter of Josiah Blanchard (24 Jun 1698-) & Mary Dudley (8 Feb 1700/1-), in Waltham, MA.30 Born on 28 Jun 1726 in Concord, MA. Abigail died in Waltham, MA, on 6 Feb 1764; she was 37.30

Children of Jonathan and Abigail (Blanchard) Peirce, born at Waltham:
i. Jonathan Peirce, b. 15 Nov 1749;
i.i Mary Peirce, b. 17 Sep 1750, d. 23 Jun 1814 unmarried;
iii. Abigail Peirce, b. 13 Aug 1757, m. 27 Jan 1785 Nathan Fiske of Reading, VT;
iv. Anna Peirce, b. 6 Apr 1759, m. 4 Dec 1784 Silas Robinson; and
v. William Peirce, b. 6 Dec 1760, m. Phebe Manning.30