On 31 Oct 1780 when John was 25, he married Elizabeth Wright, daughter of Thomas Wright (12 Dec 1709-13 Jun 1795) & Elizabeth Chandler (18 Jul 1731-6 Feb 1793), in Arlington, MA. Born ca 1757 in Woburn, MA. Elizabeth died in Winchester, MA on 18 Jul 1848.

Children of John and Elizabeth (Wright) Symmes, born at Medford:
    i. John Symmes, b. 27 Jan 1781, d. 15 Feb 1860 at Medford, m. at Woburn 28 Jun 1804 Pamelia Richardson (b. 13 Jul 1772 at South Woburn, d. 1 Dec 1845 at Medford);
    ii. Thomas Symmes, b. 30 Mar 1783, m. Sarah Lloyd Wait;
    iii. Abigail Symmes, b. 11 Feb 1785, d. 13 Aug 1863 at Medford, m. 23 May 1813 Elias Tufts (b. 9 Jan 1787 at Medford, d. there 18 Jul 1868);
    iv. Elizabeth Symmes, b. 10 Apr 1787, m. Abel Stowell;
    v. Marshall Symmes, b. 30 Jul 1789, m. at Medford 26 Jan 1818 Lephe Stowell (d. 23 Nov 1848);
    vi. William Symmes, b. 14 Aug 1791, d. in Vermont;
    vii. Ebenezer Symmes, b. 17 Aug 1793, m. at Billerica 16 May 1816 Hannah Davis (b. 13 Aug 1795 at Billerica, dau. of Timothy & Martha (Shedd) Davis);
    viii. Edmund Symmes, b. 14 Aug 1795, d. 6 Sep 1843 at Medford, m. 15 Nov 1820 Elizabeth Ann Smith (b. 27 Nov 1803); and
    ix. Charles Symmes, b. 4 Apr 1798, d. ca. 1879 at Aylmer, Canada, m. 6 Apr 1824 Hannah Ricker (b. ca. 1803 at Bath, NH, d. at Hull, Quebec, dau. of Joshua & Abigail (Chamberlain) Ricker).

In 1803 Josiah married Elizabeth Johnson (55134) , daughter of Josiah Johnson (48937) (26 Feb 1736-9 Jun 1807) & Sarah Gardner (39374) (6 Apr 1743-28 Nov 1830). Born ca 1778 in Medford, MA. Elizabeth died on 21 Jan 1857.340

Elizabeth, known as Betsey, Johnson.

Children of Josiah & Elizabeth (Johnson) Symmes, born at Medford:
    i. Elizabeth Symmes, b. 15 Aug 1804;
    ii. Josiah Symmes, b. ca. 1806, m. Sarah Butters;
    iii. Johnson Symmes, b.ca. 1808;
    iv. Jesse Symmes, b. ca. 1810;
    v. Gardner Symmes, b. ca. 1812; and
    vi. Lucy Ann Symmes, b. ca. 1814.

Abigail married Joseph Cutter.