On 17 Jul 1786 when Samuel was 18, he first married Hannah Farmer (58426) , daughter of Lieut. John Farmer (46616) (7 Dec 1736-9 Jan 1806) & Hannah Davis (50186) (7 Sep 1741-12 Feb 1787), in Billerica, MA. Born on 26 Sep 1765 in Billerica, MA.430

On 19 Nov 1795 when Samuel was 27, he second married Rebecca Butters (51299) , daughter of Samuel Butters (34148) (30 Nov 1728-7 May 1793) & Ruth Wyman (46560) (9 Nov 1734-28 Apr 1828), in Wilmington, MA.399 Born on 18 Aug 1776 in Wilmington, MA.399 Rebecca died on 23 Sep 1848; she was 72.164

Rebecca married first Samuel Hopkins; second Samuel Eames.

Children of Samuel and Rebecca (Butters) Hopkins:
    i. Rebecca Hopkins, b. 27 Jun 1799;
    ii. Lavinia Hopkins, b. 3 Jan 1801, m. Joseph Newall of Charlestown;
    iii. Samuel Hopkins, b. 1 Jul 1802;
    iv. Charles Hopkins, b. 27 Jul 1807?;
    v. Louisa Hopkins, b. 19 Jan 1807?, m. Amos Coolidge; and
    vi. Sarah Thompson Hopkins, b. 8 Aug 1813, d. 19 Sep 1844, m. 1st Joseph Bond, m. 2nd William H. Carter.209