Ca 1752 Edward first married Anna.
Children of Edward and Anna Doty, probably all born at Saybrook:
i. Anna Doty, b. ca. 1753, d. 1 Apr 1822 at Westbrook, m. 1st at Saybrook 7 Jul 1776 Abiel Lord (b. 3 Jul 1743 at Saybrook, d. ca. 1777, son of Abiel & Ann (Chapman) Lord), m. 2nd William Bartholomew (b. ca. 1759, d. 11 Dec 1822 at Saybrook, son of Samuel & Hannah Bartholomew);
ii. William Doty, b. 23 Jul 1754, d. 22 Aug 1839 at Blossvale, NY, m. at Saybrook 20 Oct 1782 Ruth Holmes (b. 25 Apr 1762 at Saybrook, d. 21 APr 1831 at Stephentown, Rensselaer Co, NY, dau of Stephen & Lucy Holmes);
iii. Sarah Doty, b. ca. 1756, m.at Saybrook 24 Nov 1784 Thomas Morehouse;
iv. Temperance Doty, b. ca. 1760, m. at Saybrook 21 Dec 1780 Robert Sheffield;
v. Edward Doty, b. ca. 1764, d. 1796 in New York, m. at Saybrook 25 Dec 1791 Rebecca Willard (b. 22 Feb 1759); and
vi. Lucinda Doty, b. ca. 1766, m. at Greenville, NY, 7 Feb 1794 Nathaniel Owen.