On 16 Sep 1720 Ephraim first married Martha Perkins (22937) , daughter of Humphrey Perkins (17 May 1661-7 Jan 1711/2) & Martha Moulton (8604) (16 Nov 1666-aft 1712), in Hampton, Rockingham County, New Hampshire.40 Born say 1700 in Hampton, Rockingham County, New Hampshire. Martha was baptized in Hampton, Rockingham County, New Hampshire, on 7 Dec 1712.

On 28 May 1739 Ephraim second married Judith Perkins in Norwich, CT. Born 2 Mar 1714/5 in Norwich, CT. Judith died in Norton, MA on 4 Sep 1740.

Judith, daughter of Jabez and Hannah (Lathrop) Perkins.

On 28 Jun 1745 Ephraim third married Meletiah Fisher, daughter of Ebenezer Fisher & Abigail Ellis, in Wrentham, MA. Born on 6 Oct 1705 in Wrentham, MA. Meletiah died in Norton, MA, on 3 Oct 1758; she was 52.

On 18 Mar 1760 Ephraim fourth married Abigail King, daughter of John King (ca 1676-5 Oct 1741) & Alice Deane (20 Nov 1678-22 May 1746), in Easton, MA. Born on 7 Jul 1710 in Raynham, MA. Abigail died in Easton, MA, on 27 Jul 1771; she was 61.

On 21 Oct 1773 Ephraim fifth married Anna Clap (44784) , daughter of Joseph Clap (25443) (14 Dec 1668-ca 1747) & Abigail Allen (28 Feb 1673/4-13 Oct 1740), in Rochester, MA. Born 1 Mar 1705/6 in Scituate, MA.52 Anna died on 7 Oct 1782.352

Anna first married Elisha Woodworth as his second wife, second Timothy Ruggles as his second wife, and third Ephraim Leonard.

Childd of Elisha and Anna (Clap) Woodworth:
    i. Hezekiah Woodworth, b. 1 Dec 1732 at Little Compton.352