On 11 Dec 1690 when Samuel was 22, he first married
Abigail Mixer, daughter of
Isaac Mixer (ca 1630-27 Nov 1716) &
Rebecca Garfield (10 Mar 1640/1-16 Mar 1682/3), in Sudbury, MA.
Born in Nov 1672 in Watertown, MA.30 Abigail died in Sudbury, MA on 26 Nov 1703.
Children of Samuel and Abigail (Mixer) Howe, born at Framingham:
i. Abigail Howe, b. ca 1691, d. 17 Sep 1722, m. Jonathan Stanhope;
ii. Samuel Howe, b. ca. 1693;
iii. Peter Howe, b. ca. 1698, d. 21 Nov 1756 at Hopkinton, MA, m. at Sudbury 9 Apr 1723 Thankful Howe (b. 15 Dec 1703 at Sudbury, d. 25 Jan 1766 at Hopkinton, dau. of David & Hepzibah (Death) Howe);
iv. Martha Howe, b. ca 1700, m. Joseph Nichols; and
v. Joseph Howe, b. ca 1702.